Mail Code: 5174
Web Site: https://chemsysbio.stanford.edu/
The department emphasizes individualized training at the interface of physical science and biomedical science. The program encourages students to draw upon a variety of modern scientific techniques, ranging from recent advances in molecular biology and protein biochemistry to synthetic organic chemistry and single cell imaging. Graduate students in the department take courses in signal transduction networks, chemical biology, and other areas of importance to their research goals.
Master of Science in Chemical and Systems Biology
Students in the Ph.D. program may apply for an M.S. degree after having satisfactorily completed the course and laboratory requirements of the first two years. The degree also requires a written thesis based on literature or laboratory research. Postdoctoral research training is available to graduates having the Ph.D. or M.D. degree.
Doctor of Philosophy in Chemical and Systems Biology
University requirements for the Ph.D. are described in the "Graduate Degrees" section of this bulletin.
The Department of Chemical and Systems Biology offers interdisciplinary training to prepare students for independent careers in biomedical science. The main focus of the program is cell signaling, chemical biology, and systems biology.
The program leading to the Ph.D. degree includes formal and informal study in chemical biology, systems biology, drug discovery, biochemistry, and other areas of relevance to the interests of particular students. First-year students spend one quarter in each of three different laboratories, working closely with other graduate students, a professor, and postdoctoral fellows on various research projects. During the fourth quarter, the student chooses a faculty mentor with whom to undertake thesis research, based on available positions and the student's interest. During or before the eighth quarter of study, students must pass a qualifying exam which consists of an oral exam on general knowledge and a defense of a research proposal. Course requirements are fulfilled during the first two years of study; the later years of the four- to six-year program are devoted to full-time dissertation research. Close tutorial contact between students and faculty is stressed throughout the program.
Research opportunities also exist for medical students and undergraduates. The limited size of the labs in the department allows for close tutorial contact between students, postdoctoral fellows, and faculty.
The department participates in the four quarter Health and Human Disease and Practice of Medicine sequence which provides medical students with a comprehensive, systems-based education in physiology, pathology, microbiology, and pharmacology.
Graduate Advising Expectations
The Department of Chemical and Systems Biology is committed to providing academic advising in support of graduate student scholarly and professional development. When most effective, this advising relationship entails collaborative and sustained engagement by both the adviser and the advisee. As a best practice, advising expectations should be periodically discussed and reviewed to ensure mutual understanding. Both the adviser and the advisee are expected to maintain professionalism and integrity.
Faculty advisers guide students in key areas such as selecting courses, designing and conducting research, developing of teaching pedagogy, navigating policies and degree requirements, and exploring academic opportunities and professional pathways.
Graduate students are active contributors to the advising relationship, proactively seeking academic and professional guidance and taking responsibility for informing themselves of policies and degree requirements for their graduate program.
For a statement of University policy on graduate advising, see the "Graduate Advising" section of this bulletin.
Emeriti: (Professors) Robert H. Dreisbach, Avram Goldstein, Dora B. Goldstein, Stuart Kim, Tag E. Mansour, Oleg Jardetzky, Richard A. Roth, James P. Whitlock
Chair: James K. Chen
Professors: James K. Chen, Karlene A. Cimprich, James E. Ferrell, Jr., Tobias Meyer, Daria Mochly-Rosen, Thomas J. Wandless, Joanna K. Wysocka
Professor (Teaching): Kevin Grimes
Assistant Professors: Joshua Elias, Daniel F. Jarosz, Lei Stanley Qi, Mary Teruel
Courtesy Professors: Philip Beachy, Carolyn Bertozzi, Matthew Bogyo, Beverly S. Mitchell, Paul A. Wender
Courtesy Associate Professors: Markus W. Covert, Justin Du Bois, Michael Z. Lin, Jan M. Skotheim, Aaron F. Straight, Marius Wernig
CSB 199. Undergraduate Research. 1-18 Unit.
Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
CSB 201. Chemical and Systems Biology Bootcamp. 1 Unit.
In this "boot camp" students perform hands-on original research in small groups, combining chemical biology systems-level approaches to investigate current biological problems. This year's course will investigate the function and regulation of uncharacterized genes. Students will acquire conceptual and methodological training in a wide range of modern techniques, including "omics" approaches, fluorescence microscopy, genome editing, computational approaches, and quantitative data analysis.
CSB 210. Cell Signaling. 4 Units.
The molecular mechanisms through which cells receive and respond to external signals. Emphasis is on principles of cell signaling, the systems-level properties of signal transduction modules, and experimental strategies through which cell signaling pathways are being studied. Prerequisite: working knowledge of biochemistry and genetics.
CSB 220. Chemistry of Biological Processes. 3 Units.
The principles of organic and physical chemistry applied to biomolecules. The goal is a working knowledge of chemical principles that underlie biological processes. Chemical tools and techniques used to study and manipulate biological systems may be used to illustrate these principles. Prerequisites: organic chemistry and biochemistry, or consent of instructor.
CSB 221. Methods and Logic in Chemical and Systems Biology. 2 Units.
This course covers logic, experimental design and methods in Chemical and Systems Biology, using discussions of classic and modern literature to discern the principles of biological investigation in making discoveries and testing hypotheses. In collaboration with faculty, students also apply those principles to generate a potential research project, presented in both written and oral form.
CSB 222. Imaging: Biological Light Microscopy. 3 Units.
This intensive laboratory and discussion course will provide participants with the theoretical and practical knowledge to utilize emerging imaging technologies based on light microscopy. Topics include microscope optics, resolution limits, Köhler illumination, confocal fluorescence, two-photon, TIRF, FRET, photobleaching, super-resolution (SIM, STED, STORM/PALM), tissue clearing/CLARITY/light-sheet microscopy, and live-cell imaging. Applications include using fluorescent probes to analyze subcellular localization and live cell-translocation dynamics. We will be using a flipped classroom for the course in that students will watch iBiology lectures before class, and class time will be used for engaging in extensive discussion. Lab portion involves extensive in-class use of microscopes in the CSIF and NMS core microscopy facilities.
Same as: BIO 152, MCP 222
CSB 224. Chemical and Systems Biology Pizza Talks. 1 Unit.
Required of and limited to all graduate students and postdoctoral scholars in the Department of Chemical and Systems Biology. Students and postdocs are required to give in-depth presentations about their current projects within the academic year.
CSB 240A. A Practical Approach to Drug Discovery and Development. 3-4 Units.
Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour.
CSB 240B. A Practical Approach to Drug Discover and Development. 3-4 Units.
(Continuation of 240A) Advancing a drug from discovery of a therapeutic target to human trials and commercialization. Topics include: high throughput assay development, compound screening, lead optimization, protecting intellectual property, toxicology testing, regulatory issues, assessment of clinical need, defining the market, conducting clinical trials, project management, and commercialization issues, including approach to licensing and raising capital. Maximum units are available by taking an additional contact hour. Prerequisite: 240A.
CSB 242. Drug Discovery and Development Seminar Series. 1 Unit.
The scientific principles and technologies involved in making the transition from a basic biological observation to the creation of a new drug emphasizing molecular and genetic issues. Prerequisite: biochemistry, chemistry, or bioengineering.
CSB 244. Drug Discovery and Development: A Case-based Approach. 2 Units.
Provides an overview of the drug discovery and development process through use of case examples--successful and unsuccessful attempts to integrate the scientific, clinical, regulatory, and commercial requirements to bring a new drug to patients. Focus on the complex array of independent tasks that must be accomplished to bring a new drug to the clinic. Specific cases discussed in a seminar format.
CSB 245. Economics of Biotechnology. 2 Units.
Focuses on translation of promising research discovery into marketed drugs and the integration of scientific method, clinical needs assessment, clinical and regulatory strategy, market analysis, economic considerations, and the influence of the healthcare economic ecosystem necessary for successful translation. Explores the economic perspectives of various stakeholders--patients, providers, payers, biotechnology and pharmaceutical companies, FDA, and financial markets--and how they influence drug development.
CSB 250. The Biology of Chromatin Templated Processes. 3 Units.
Topics include mechanisms of DNA replication; gene expressions regulation; DNA damage sensing and DNA repair; chromatin structure and function; and epigenetics and nuclear reprogramming. Prerequisite: working knowledge of molecular biology, biochemistry and genetics, or instructor consent.
CSB 260. Concepts and Applications in Chemical Biology. 3 Units.
Current topics include chemical genetics, activity-based probes, inducible protein degradation, DNA/RNA chemistry and molecular evolution, protein labeling, carbohydrate engineering, fluorescent proteins and sensors, optochemical/optogenetic methods, mass spectrometry, and genome-editing technologies.
CSB 261. Quantitative Principles in Cell Differentiation. 3 Units.
Explores the common principles controlling cell differentiation from stem cells to terminally differentiated cells. Focus is on becoming familiar with the computational and single-cell experimental approaches that are needed to identify, probe, and dissect the dynamic decision to differentiate or de-differentiate in different cell systems including stem cells, adipocytes, neurons, pancreatic beta cells, cardiomyocytes, and hematopoietic cells. Topics include exploring how feedback mechanisms can be exploited to enable and precisely control tissue regeneration.
CSB 270. Research Seminar. 1 Unit.
Guest speakers and discussion on current research in pharmacology.
CSB 271. Principles of Cell Cycle Control. 3 Units.
Genetic analysis of the key regulatory circuits governing the control of cell division. Illustration of key principles that can be generalized to other synthetic and natural biological circuits. Focus on tractable model organisms; growth control; irreversible biochemical switches; chromosome duplication; mitosis; DNA damage checkpoints; MAPK pathway-cell cycle interface; oncogenesis. Analysis of classic and current primary literature. Satisfies Central Menu Area 2.
Same as: BIO 171, BIO 271
CSB 272. Research Ethics. 1 Unit.
Preference to Chemical and Systems Biology students and postdoctoral fellows. Focus is on responsible conduct of research with a combination of didactic lectures and in-class activities. Topics include ethical issues in research, interpersonal responsibility, professional responsibility, and human and animal participation in research.
CSB 290. Curricular Practical Training. 1 Unit.
CPT Course required for international students completing degree requirements.
CSB 299. Directed Reading in Chemical and Systems Biology. 1-18 Unit.
Prerequisite: consent of instructor.
CSB 346. Advanced Seminar on Prokaryotic Molecular Biology. 1 Unit.
CSB 370. Medical Scholars Research. 4-18 Units.
Provides an opportunity for student and faculty interaction, as well as academic credit and financial support, to medical students who undertake original research. Enrollment is limited to students with approved projects.
CSB 399. Graduate Research. 1-18 Unit.
Students undertake investigations sponsored by individual faculty members. Prerequisite: consent of instructor.
CSB 801. TGR Project. 0 Units.
CSB 802. TGR Dissertation. 0 Units.